Cardinals Odds

Arizona is starting over after one of the worst seasons in franchise history. The Cardinals went 3-14, the most losses the team has ever recorded, and fired Jonathan Gannon after three years. The new man in charge is Mike LaFleur, hired off Sean McVay’s Rams staff to rebuild the offense and the culture.

The quarterback picture is unsettled, the roster is thin, and the division is brutal. This is year one of a reset, and the schedule opens on the road against a Chargers team favored by double digits. Patience is the watchword in the desert.

Lucky Rebel’s Editor Top Pick

This is a rebuild, plain and simple. Mike LaFleur arrives from the league’s top offense in Los Angeles, tasked with developing a quarterback room headed by Jacoby Brissett and rebuilding a roster that won three games. Kyler Murray is gone. The Cardinals hold premium draft capital and a new offensive-minded staff, but the pieces are not in place yet. The bet here is on the foundation, not the 2026 win total.

Cardinals next game odds

Arizona Cardinals at Los Angeles Chargers · 9/13/26 · 1:25 PM PT

Team	Spread	Moneyline	Total
Arizona Cardinals	+10.5 (-110)	+460	O 46.0 (-110)
Los Angeles Chargers	-10.5 (-110)	-675	U 46.0 (-110)

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Cardinals to make the playoffs

Market	Yes	No
Arizona Cardinals to make the playoffs	+1500	-6000

Our call: they miss it. At +1500 to make the playoffs and -6000 to miss, the market has Arizona as one of the longest shots in the league, and the 3-14 finish explains why. A new head coach, a new coordinator and an unsettled quarterback room in the toughest division in football do not add up to January. The Cardinals are building, and 2026 is about establishing an identity, not chasing a playoff berth.

Mike LaFleur takes over a rebuild

LaFleur comes to Arizona after three seasons on Sean McVay’s staff in Los Angeles, the last as offensive coordinator of a Rams offense that finished first in points and yards. He is a McVay coaching-tree product and an offensive play-caller, hired to fix a unit that fell apart in 2025. General manager Monti Ossenfort stays to oversee the rebuild.

The Cardinals fired Jonathan Gannon after a 3-14 collapse that ended on a nine-game losing streak. The reset is real, from the head coach down. LaFleur’s first job is to find out what he has at quarterback and build an identity from there.

Nathaniel Hackett, Nick Rallis and the staff

Nathaniel Hackett arrives as offensive coordinator, reuniting with the LaFleur coaching family after years working alongside Mike’s brother Matt in Green Bay. He replaces Drew Petzing and is tasked with installing the new offense around whoever wins the quarterback job.

Nick Rallis stays as defensive coordinator, the one piece of continuity on the staff. Entering his fourth year running the Arizona defense, Rallis has yet to push the unit into the league’s top half, and doing so is central to the team taking a step in 2026.

The Cardinals playing staff

The quarterback room defines the season. Jacoby Brissett, who started twelve games in 2025 after Kyler Murray went down with a foot injury, is under contract, and Murray has moved on to Minnesota. The Cardinals hold premium draft capital to keep building at the position and elsewhere.

The roster around the quarterback is thin, a rebuild in progress under a new staff. The defense under Rallis has to take a step, and the offense has to find an identity. Arizona is laying a foundation in 2026, and the wins should follow later.

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